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Are Higher CFU Probiotics More Effective? How to Choose the Ideal Probiotic?

December 06, 2023

probiotics CFU

In our everyday conversations, we often hear terms like lactobacillus, AB bacteria, probiotics, intestinal flora, and prebiotics, underscoring the crucial role of probiotics in health. But do you truly understand what probiotics are? Ever pondered the meaning behind the numbers like "10 billion, 30 billion, 40 billion, 50 billion, or even 100 billion bacteria" on health supplement labels? These figures represent "CFU" (Colony-Forming Units), a key metric for evaluating the activity and effectiveness of probiotics.
 

Our gut is home to a diverse microbial world, with over 400 different types of bacteria totaling an astonishing 100 trillion. These are categorized into beneficial bacteria (probiotics, symbiotics), neutral bacteria (opportunistic, conditionally pathogenic), and harmful bacteria (pathogens). The dynamic equilibrium of these microbial populations is essential for maintaining gut health. This article explores the varieties and advantages of probiotics and the pivotal role of CFU in determining probiotic efficacy, helping you make well-informed decisions about probiotic products.


 

What Are Probiotics?

Probiotics, simply put, are beneficial active microorganisms that contribute to our health - they are the 'good bacteria' in our body. This group includes various bacteria, like lactobacilli and yeast, that support our health through mechanisms such as protecting the intestinal tract, facilitating bowel movements, and modulating the immune system.
 

Probiotics form a protective barrier on our intestinal mucosa, shielding against invading pathogens. A higher ratio of probiotics in our gut equates to healthier, more vibrant intestines, decreasing the production of bodily toxins and lessening the detoxification load on the liver.
 

Furthermore, prebiotics, also known as symbiotics or probiotic enhancers, are essentially food for probiotics. Adequate prebiotic intake fosters the colonization and growth of probiotics in the intestines. Common prebiotics include oligosaccharides and dietary fibers, integral to maintaining gut health.
 

Common Probiotics Strains

Let's talk about common probiotics and their health benefits. The true essence of probiotics' health value is rooted in their distinct strains. Dominating the probiotic landscape, 90% are lactobacilli, with well-known varieties like Lactobacillus acidophilus and Lactobacillus paracasei 33 (LP33). Complementing them are bifidobacteria, such as Bifidobacterium, crucial in warding off intestinal pathogens and preserving gut flora equilibrium.
 

Probiotics' advantages reach far beyond gut health. Selected strains are acclaimed for enhancing skin health, easing allergies, and positively impacting cardiovascular wellness. They play a pivotal role in synthesizing crucial nutrients, including Vitamin K and various B-vitamins, indispensable for blood coagulation, energy metabolism, and maintaining neurological health.
 

It's intriguing to note that different probiotic strains cater to specific health needs. For example, Lactobacillus rhamnosus GG (LGG) is renowned for its proven efficacy in managing and preventing diarrhea in children, while Bifidobacterium lactis is particularly effective in relieving constipation. Nonetheless, it's vital to remember that individual responses to probiotics can vary, highlighting the uniqueness of each person's health profile.
 

The Impact of Gut Flora Imbalance: Understanding Dysbiosis

Ever curious what happens when the balance of good and bad bacteria in our gut shifts unfavorably? This condition, known as gut flora imbalance or dysbiosis, can have far-reaching effects on our health. Factors like diet, medication, the state of the gut lining, immune system, environmental factors, and even microbial interactions can influence the balance of our gut microbiota. Under stress, these elements may disrupt the delicate equilibrium of our gut flora. Typically, dysbiosis refers to a reduction in beneficial bacteria and an increase in harmful bacteria, leading to issues like:

  • Digestive System Disorders: Imbalance in gut flora can trigger intestinal inflammation, increasing the risk of Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD). It may also lead to symptoms of indigestion, such as bloating, constipation, or diarrhea.
  • Immune System Dysfunction: The gut flora is closely linked to immune function. Imbalance can impair or overactivate immune responses, raising the risk of infections and autoimmune diseases.
  • Obesity and Metabolic Diseases: Research indicates a connection between the composition of gut flora and weight and metabolic health. Certain imbalances might be associated with increased risks of obesity, Type 2 diabetes, and metabolic syndrome.
  • Mental Health Issues: There is a strong link between the gut and mental health. Dysbiosis might relate to mental health problems like anxiety and depression.
  • Skin Conditions: Gut flora impacts skin health. Skin disorders such as eczema and acne might be linked to imbalances in gut microbiota.
  • Neurological Impact: The brain and gut are interconnected through the gut-brain axis. For instance, gut flora imbalance might be related to neurodegenerative diseases like Parkinson's disease.

Maintaining the balance of our gut flora is vital for our health. Strategies like healthy eating, regular exercise, managing stress effectively, and careful antibiotic use are key. Moreover, using probiotic supplements, supported by scientific research, is also deemed helpful for gut flora health.




 

Health Benefits of Probiotics

Let's dive into the diverse health benefits of probiotics. Through this comprehensive list, you'll gain an in-depth understanding of the various advantages of probiotics, their specific functions, the recommended strains, and scientific references that enhance your knowledge about the effectiveness of probiotics.
 

  Benefit Description Recommended Probiotic Strains Reference
1 Gut Health Supports digestive health, improves gut microbiota balance, enhances intestinal integrity Lactobacillus acidophilus, Streptococcus thermophilus, Bifidobacterium bifidum, Lactobacillus rhamnosus, Lactobacillus plantarum PubMed 9728474
2 Diarrhea Relief Eases symptoms of acute diarrhea in children, helps restore gut flora balance Saccharomyces boulardii, Lactobacillus rhamnosus (LGG), Lactobacillus reuteri, Bifidobacterium longum PubMed 8706888
3 Constipation Improvement Enhances bowel movement, aids in relieving functional constipation Bifidobacterium lactis PubMed 25099542
4 Immune Support Boosts immunity, balances inflammatory and anti-inflammatory cytokines Lactobacillus paracasei, Lactobacillus plantarum, Bifidobacterium bifidum, Lactobacillus reuteri, Lactococcus lactis PubMed 33828554, PubMed 9818925
5 Allergy Alleviation Helps relieve symptoms of allergic rhinitis, reduces Th1:Th2 ratio Lactobacillus paracasei 33 (LP-33), Lactobacillus rhamnosus PubMed 27442711
6 Vaginal Infections Assists in reducing recurrence of common vaginal infections in non-pregnant women Lactobacillus reuteri, Lactobacillus gasseri PubMed 7444381
7 Oral Health Improves oral hygiene, reduces cariogenic bacterial colony counts Lactobacillus salivarius, Lactobacillus plantarum, Bifidobacterium lactis, Lactobacillus acidophilus PubMed 28390121
8 Cholesterol Management Helps manage high cholesterol, lowers total and LDL cholesterol L. reuteri, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus paracasei PubMed 5464580
SCIENCE 2018-15096
9 Sleep Aid Potentially improves subjective sleep quality Lactobacillus rhamnosus, Lactobacillus gasseri, L. reuteri, Bifidobacterium adolescentis PubMed 5449130
ACADEMIC 13594
MDPI-2660
10 Psychological Stress Reduction Helps lower subjective stress levels, improves anxiety and depression levels Bifidobacterium longum, L. reuteri, Bifidobacterium adolescentis PubMed 32662591
MDPI-2660
11 Weight Management Regulates metabolism, assists in reducing BMI, waist, and hip size Lactobacillus gasseri, Lactobacillus casei PubMed 33669580


While probiotics can provide substantial health benefits, it's important to note that more scientific validation is needed due to the variability and limitations in the scale of studies.

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The Dual Challenge of Probiotic CFU

1. The Brief Yet Critical Life Journey of Probiotics

Probiotics, the guardians of our health, rely on billions, even trillions, of living microbes to reach the gastrointestinal tract effectively. Yet, these tiny warriors embark on a brief but vital journey. Their survival can vary significantly depending on the strain, storage conditions, and environmental factors, with some strains living just 48 hours. This colonization process resembles the narrative of "Passengers," where strains undergo a space-like hibernation journey to a new colony. If they wake up too soon, they face a countdown to survival.
 

Colony Forming Units (CFU) serve as a crucial measure of probiotic potency. The strain's type, characteristics, and its interaction with our bodies are equally pivotal. The CFU count on products reflects the number of viable microbes, which must endure the stomach's acidity and thrive in the intestines to benefit health.
 

2. Delicate Survival Conditions

Most probiotic strains are extremely delicate and sensitive to environmental conditions, easily affected by heat, light, oxygen, pressure, and moisture. To ensure these live bacteria safely reach the intestines and perform effectively, they need to be carefully protected right from the source.
 

These strains ideally should enter a dormant or hibernation state after birth to ensure survival during storage. This includes maintaining them in a dormant state during storage and transportation until they successfully reach the intestines and are activated. This strategy helps maintain the CFU count of the probiotics and minimizes loss during digestion, ensuring they are in optimal condition when they arrive in the colon for maximum positive health impact.
 

How to Select the Right Probiotic Product for Your Health Need?

Probiotics, often hailed as tiny helpers for enhancing health, require a thoughtful approach when it comes to selecting the right product. Let me walk you through step by step to choose the most suitable probiotic tailored to your need:

  • Strategic Strain Selection: Each probiotic strain offers specific health benefits. Pinpointing the strain that resonates with your health needs, backed by scientific research, is crucial.
  • Effective CFU Dose Determination: The CFU (Colony Forming Units) measure is key to evaluating a product's efficacy. Remember that higher CFU count doesn’t always mean better results. It's vital to choose a product with a CFU count that promises optimal effectiveness.
  • Choosing Protective Formulations: The choice of formulation is critical in safeguarding the probiotic's viability. Ensuring the manufacturing process is friendly to the probiotics is essential to maintain optimal activity and CFU.
  • Opting for Suitable Packaging: Probiotics are delicate and sensitive to heat, light, oxygen, and more. Selecting packaging that effectively protects the strains is paramount for maintaining their stability and potency.
  • Proper Storage Condition: Depending on the specific traits of the strains, choosing the right storage and transport conditions is crucial to preserve the probiotics' optimal activity.
  • Incorporating Prebiotics: Products enriched with prebiotics can boost the growth and survival of probiotics in the gut. Their inclusion, however, should align with the specific purpose of the product.
  • Seeking Professional Certification: Opt for products that have been certified by professional health organizations to ensure quality and safety.
  • Consulting Healthcare Professionals: If you have specific health concerns, consulting a doctor or nutritionist before choosing a probiotic is advisable to ensure it meets your health requirements.

This guide is designed to help you confidently navigate the diverse range of probiotic products, ensuring you select one that best enhances your health and well-being.

〈Extended reading:Unraveling Probiotics: Savor and Absorb Through Delectable Candy-like Dosage Supplements!
 



Probiotic Preservation: Boncha Bio's Candyceutical Dosage with 'Hibernation' Technology

Boncha Bio, leveraging advanced formulation technology and in-depth probiotic expertise, introduces a new generation of candyceutical dosage form. Tailored to enhance both the survival and efficacy of probiotics, this innovative design is a leap forward in probiotic delivery. Our unique process, uses low water activity techniques in a low-temperature, low-pressure environment, ensures that probiotics enter a hibernation-like state. This approach enables probiotics to maintain maximal activity and potency, even over storage periods extending from several months to a year.
 

Our formula goes beyond mere protection; it effectively boosts the probiotics' successful colonization in the gastrointestinal tract, thereby amplifying their health benefits. Moreover, we've enriched the outer layer of our candy capsules with ProbioBooster prebiotics – the favorite food of probiotics – akin to providing them with a self-contained food and nutrient source, further boosting their survival rate.


At Boncha Bio, we are dedicated to enhancing the preservation rate of probiotics' CFU through this innovative technology, delivering enhanced health benefits to consumers. If our innovative approach and products pique your interest, or if you're keen to discover how we're redefining healthcare solutions, we warmly invite you to reach out to us. Join us in exploring how this pioneering technology can be integrated into your products, offering superior health choices to a broader audience.

 

〈Extended reading: Harnessing the Power and Efficacy of Functional Candies: A New Era in Nutritional Supplements with ODM Candy-like Capsules


保健品代工需求請諮詢糖化生醫

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