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How to Effectively Supplement Hyaluronic Acid, Collagen, and Ceramide to Restore Skin and Joint Health?

October 24, 2024


As we age, have you noticed your skin no longer feels as smooth and hydrated? Are your joints stiffening, and your nails and hair becoming brittle? These changes are often linked to the gradual loss of three key components: Hyaluronic Acid, Collagen, and Ceramide.
 

•    Hyaluronic Acid: After age 30, the body’s ability to produce hyaluronic acid drops by around 50%, potentially leading to a 30-40% reduction in skin hydration, though the rate varies based on factors like genetics and lifestyle.

•    Collagen: Collagen levels begin declining around age 20, decreasing by about 1% per year. By 40, collagen may reduce by 20-30%, and by 50, the loss often exceeds 30%. These figures also vary with individual factors.

•    Ceramide: By 40, ceramide levels in the epidermis can drop by 60% compared to age 20, weakening the skin's barrier, leading to dryness and sensitivity.

These three components are essential for maintaining skin and joint health. As they diminish, skin condition, joint flexibility, and overall health are affected. While a natural part of aging, supplementing with hyaluronic acid, collagen, and ceramide can effectively address these concerns.
 

What Are Hyaluronic Acid, Collagen, and Ceramide? Why Do We Need Them?

Hyaluronic acid, collagen, and ceramide naturally decrease as we age. Let's take a closer look:

•    Hyaluronic Acid: A naturally occurring polysaccharide, also known as "hyaluronan." It is a transparent, viscous liquid composed of D-glucuronic acid and N-acetylglucosamine. Each gram can absorb 500-1000 milliliters of water, with absorption varying by molecular weight. Its primary role is to keep skin hydrated and joints lubricated. It also helps stabilize collagen.

•    Collagen: A protein that supports skin, bones, tendons, and joints. It is broken down into smaller peptides and amino acids, which are absorbed and promote collagen synthesis. Vitamin C is crucial for collagen production.

•    Ceramide: A key lipid in the skin’s barrier. Along with hyaluronic acid and collagen, ceramide maintains skin moisture and integrity, aids in cell signaling, and protects the skin from external damage.
These components are essential for maintaining skin health and supporting both appearance and internal function.
 

Ingredient

Chemical Structure/Classification

Functional Mechanism

Distribution
(based on proportion)

Hyaluronic Acid

• Chemical Structure: Polysaccharide polymer composed of D-glucuronic acid and N-acetylglucosamine
• Molecular Weight Classification:
- High molecular weight: >1,000 kDa
- Medium molecular weight: 100-1,000 kDa
- Low molecular weight: <100 kDa

• Deep moisturizing ability: 1g can absorb 500~1000ml of water
• Lubricating action: reduces joint friction
• Promotes wound healing
• Anti-inflammatory properties

1. Skin
2. Joints
3. Eyes
4. Other tissues

Collagen

Structural protein, main types:
- Type I (80-90%): Skin, Bones
- Type II (5-10%): Cartilage
- Type III (8-10%): Blood vessels, Organs
- Type IV: Basement membrane
- Type V: Fiber formation

• Provides structural support
• Maintains tissue elasticity
• Promotes wound healing
• Strengthens bone density

1. Skin
2. Bones
3. Cartilage
4. Other

Ceramide

Lipid molecules, with 9 main subtypes:
- EOS: Most important barrier lipid
- NS: Excellent moisturizing effect
- NP: Strengthens the stratum corneum structure
- AP: Improves skin elasticity
- EOP: Maintains skin pH balance

• Forms layered structure
• Strengthens skin barrier
• Regulates water loss
• Cell signaling

1. Stratum corneum
2. Granular layer
3. Spinous layer

 

Not Just for External Beauty—The Equal Importance of Hyaluronic Acid, Collagen, and Ceramide for Internal Health and Eye Health

Hyaluronic acid, collagen, and ceramide play crucial roles not only in beauty and skincare but also in supporting internal body functions and eye health.
 

 

Area

Ingredient

Benefits

References

External Beauty

Skin

Hyaluronic acid

Acts like cement for the skin, deeply hydrates, reduces fine lines and dryness, keeping it youthful and plump.

PUBMED 28761365
PUBMED 34203487

Collagen

Provides structural support to the dermis, maintains elasticity and firmness, reduces sagging, giving skin resilience and smoothness.

PUBMED 33742704
PUBMED 30681787

Ceramide

Strengthens the skin barrier, prevents moisture loss, and reduces sensitivity and dryness.

Ceramides For Skin-Review

Internal Body Functions

Joint Health

Hyaluronic acid

Lubricates joints, reduces friction, protects cartilage from wear, and improves joint flexibility.

PMC4729158
Hyaluronic Acid (HA) For Knee
PUBMED 23226979

Collagen

The main structural protein in joint cartilage, providing support and preventing age-related degradation.

PMC10058045

Repair Function

Hyaluronic acid

Accelerates wound healing, maintains a moist environment, and prevents infections.

PMC7570474/

Collagen

Promotes wound healing and repairs damaged tissue, crucial for skin and connective tissue recovery.

PMC8303758

Ceramide

Strengthens the skin barrier, minimizes external damage, and speeds up skin repair.

Ceramides For Skin Repair-Review

Eyes

Eye Health

Hyaluronic acid

Provides moisture, relieves dry eyes, maintains corneal health, and reduces discomfort—especially beneficial for screen users and contact lens wearers. Some contact lenses include hyaluronic acid for added hydration.

PUBMED 31662894

Collagen

The main structural protein in the corneal matrix, supporting corneal function and health.

PMC8696667

Ceramide

Maintains moisture and barrier function around the eyes, preventing dryness and environmental irritation.

 

  

Daily Diet for Supplementing Hyaluronic Acid, Collagen, and Ceramide



We can naturally supplement hyaluronic acid, collagen, and ceramide through your daily diet. Below are the recommended food sources:
 

Hyaluronic Acid

Hyaluronic acid is naturally found in the connective tissues of animals. Common dietary sources include:
1.    Bone broths and cartilage: Chicken, pork, and fish bone broths are rich in hyaluronic acid and gelatin, which help moisturize and lubricate, making them a traditional source of supplementation.
2.    Animal organs: Chicken combs, animal cartilage, and pork skin contain high levels of hyaluronic acid. Consume in moderation to avoid excess fat and cholesterol.
 

Collagen

Collagen can be obtained from high-protein foods, with main sources including:

1.    Fish: Especially deep-sea fish, where the skin and bones are rich in collagen. The small molecular structure of fish collagen allows for effective absorption.
2.    Protein-rich foods: Chicken, beef tendons, and pig's feet are rich in high-quality proteins, supplying the amino acids needed for collagen synthesis.
3.    Fruits and vegetables: Vitamin C-rich fruits (such as oranges, lemons, and acerola cherries) promote collagen production, while vegetables like spinach and kale provide antioxidants to prevent collagen breakdown.
 

Ceramide

Ceramide is found in various natural foods, with key sources including:
1.    Whole grains: Brown rice, whole wheat bread, oatmeal, and unpolished rice are rich in ceramides, which help strengthen the skin barrier.
2.    Soy products and tofu: Ceramides in soy products help the skin retain moisture and maintain a healthy barrier.
3.    Others: Golden mushrooms are another source of ceramides.
 

Ingredient

Food Sources

Key Benefits

Supplementation Recommendations

Hyaluronic Acid

Chicken combs, animal cartilage, pork skin, bone broth

Hydrates skin, lubricates joints, reduces wrinkles

Consume fatty parts in moderation; bone broth is recommended for enhanced absorption

Collagen

Fish skin, chicken skin, pig's feet, beef tendons, bone marrow soup

Maintains skin elasticity, supports joint health

Gelatin-rich foods like fish skin and pig’s feet promote both skin and joint health

Ceramide

Whole grains (brown rice, whole wheat bread, oatmeal), soy products (tofu)

Locks in moisture, strengthens skin barrier

Combine whole grains and soy products to continually boost ceramide intake and enhance skin barrier function



Comparison of Existing Supplementation Methods for Hyaluronic Acid, Collagen, and Ceramide

There are various ways to supplement hyaluronic acid, collagen, and ceramide, each offering distinct advantages and limitations. Below is a detailed comparison:
 

Method

Advantages

Disadvantages

Suitable for

Molecular Size Description

Injection

- Fast and noticeable results
- Targeted treatments for specific areas

- Requires regular treatments, expensive
- Higher risk with potential side effects

Ideal for individuals seeking quick improvements in appearance, such as reducing wrinkles or filling depressions

Hyaluronic acid and collagen in injections are typically large molecules, ideal for filling and partial enhancements

Topical Application

- Easy to use, suitable for daily care
- Effective for surface hydration

- Large molecules, difficult to penetrate deeply into the skin
- Short-term effects

Best for those focused on surface care and daily maintenance

Most topical products contain large molecules that remain on the skin’s surface, offering temporary hydration.
Some new product with small-molecule technology may achieve better penetration

Oral Supplements

- Provides long-lasting hydration from within
- Suitable for long-term care

- Requires consistent use to see noticeable effects

Ideal for those seeking overall body care and appearance

Oral products often use small molecule technology, making them easier to absorb, providing deeper hydration and repair



Hyaluronic Acid

1.    Injection

A. Hyaluronic acid injections are widely used in aesthetic medicine to smooth wrinkles and fill depressions. In medical treatments, it is injected into the knee joint to stimulate production, reducing pain and inflammation.
B. The hyaluronic acid injections typically use large-molecule hyaluronic acid, ideal for deep skin repair. While results are significant, regular treatments are required to maintain effects.
C. Commonly sourced from Streptococcus fermentation or chicken comb extract, hyaluronic acid has a well-established safety record. However, it's essential to consult a trusted physician for these treatments.
 

2.    Topical Application

Hyaluronic acid in topical products, such as serum and skincare, is used for daily care, focusing on surface hydration. Due to its large molecules, it struggles to penetrate deeply, offering mainly short-term hydration and appearance improvements.
 

3.    Oral Supplements

Oral hyaluronic acid products typically utilize small-molecule designs for better absorption, offering long-lasting hydration and repair from within.
 

Collagen

1.    Injection

Collagen injections are frequently used in aesthetic treatments to fill skin depressions and support soft tissue. While large molecules metabolize slowly, they provide deep repair and lifting effects.
 

2.    Topical Application

Collagen skincare products mainly offer short-term surface care, as collagen cannot penetrate deeply into the skin's dermis , temporarily improving the skin's appearance.
 

3.    Oral Supplements

Oral collagen supplements are designed with small molecules, is ideal for full-body care. It penetrates connective tissues to help repair skin and joints.


Ceramide

1.    Topical Application

Ceramide is in skincare products strengthens the skin barrier and prevents moisture loss. As a lipid molecule, it remains on the skin's surface, offering immediate hydration and protection.
 

2.    Oral Supplements

Oral ceramides strengthen the skin barrier from within, aiding moisture retention and protection against irritants. Often derived from plant extracts like brown rice or golden mushrooms, they are easily absorbed to promote overall skin health.
 

How Small-Molecule Technology Enhances Absorption

Modern nutraceutical technology uses small-molecule hyaluronic acid, collagen, and ceramide to improve absorption. Boncha Bio's products feature high-purity hyaluronic acid from Streptococcus fermentation, combined with small-molecule collagen, which are more easily absorbed by the body, providing deep hydration, repair, and enhanced skin barrier function.
 

Recommended Beauty and Wellness Formulas—Enhancing Skin and Joint Care

When supplementing with hyaluronic acid and collagen, experts recommend combining them with key nutrients to significantly enhance their effects.

Vitamin C plays a vital role in collagen production. As a powerful antioxidant, it protects cells from free radical damage and promotes collagen synthesis. Combined with other antioxidants, Vitamin C further improves the absorption and effectiveness of both collagen and hyaluronic acid.

Additionally, glucosamine and UC-II (Type II Collagen) are ideal for joint health. Paired with hyaluronic acid, they enhance joint lubrication, reduce friction, and lower the risk of inflammation.

Ceramide is equally important. As a key component for maintaining a healthy skin barrier, it boosts moisture retention, leaving the skin more hydrated and smooth. Combining these ingredients offers a comprehensive solution for skin, joint, and overall health.
 

Boncha Bio's Innovative Beauty Care Candy Capsules



Boncha Bio stands out with its next-gen, user-friendly candy capsules that use small-molecule technology to enhance absorption. With high-purity hyaluronic acid and collagen, these capsules deliver deep nourishment to the skin and support overall health.

Key ingredients—hyaluronic acid, ceramide, and Vitamin C—work synergistically to hydrate, maintain elasticity, and strengthen the skin barrier. Ceramide helps repair the skin, while Vitamin C's antioxidant properties enhance texture and help prevent aging.

The formula also includes collagen peptides or fish collagen, providing comprehensive repair and protection for both skin and joints. This holistic anti-aging approach promotes a youthful appearance and supports overall vitality, making it ideal for daily care.

Boncha Bio's candy capsules offer an effective, enjoyable, and convenient solution for beauty and wellness, addressing both skin health and joint function. Experience the future of beauty care with Boncha Bio's advanced dosage form. Contact us today!


〈Extended reading:Candy Capsules vs. Functional Gummies: The Ultimate Guide to Your Wellness Choices
〈Extended reading:Harnessing the Power and Efficacy of Functional Candies: A New Era in Nutritional Supplements with ODM Candy-like Capsules

保健品代工需求請諮詢糖化生醫
 

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